Cannabis can help with depression through a number of cannabinoids and terpenes that work together through the Entourage Effect. One of the main ways cannabis combats depression is due to the positive effect CBD has on the production of serotonin by acting on the 5HT1A receptors in the brain. This effect is amplified by terpenes such as limonene and caryophyllene. 

THC, on its own, acts on the CB1/CB2 receptors, creating a buffer against depression due to its psychoactive effect (in low to medium doses). Together, THC and CBD can alleviate the major symptoms of depression like; insomnia, fatigue, loss of appetite and chronic pain.

According to the World Health Organisation (WHO more than 300 million people across the world experience depression. If you’re experiencing anxiety, low self-esteem, chronic stress and or a lack of appetite and sleep, there is a distinct possibility that you could be one of those millions who is currently fighting depression.

But have you considered the possibility that medical marijuana could actually be used to treat depression?

The common symptoms of depression include continuous low mood or sadness, feeling hopeless and helpless, having low self-esteem and or feelings of anxiety.

While pharmaceutical drugs remain the most common treatments for depression, many more people are now considering several alternatives like medical cannabis. 

Indeed, in recent years, a growing body of scientific research has come to light, indicating strongly that medical marijuana has serious potential in helping to reduce the symptoms related to depression.

Research Highlights the Efficacy of Cannabis as a Treatment for Depression

The fascinating world of cannabis health continues to arouse the curiosity of scientists around the globe. As such, it was only natural for them to study the potential effects and medical benefits that medical cannabis could have when used as a treatment for the depression crisis that seems to be engulfing so much of our planet.

In September of 2019, a study published in the Journal of Affective Disorders, suggested that inhaling cannabis can significantly reduce short-term levels of depression. Of those taking part in the analysis, 89.3% experienced a significant reduction in feelings of depression. 

The analysis also revealed that cannabis was effective in reducing anxiety (over the short-term) and stress. Another study conducted in 2014 was carried out to understand the effects of CBD, one of the dominant cannabinoids in the cannabis plant. The analysis revealed that CBD interacted with the serotonin receptors in our brain, which, in turn, helped to lower anxiety and depression levels. 

As the level of research on cannabis increases, It is now thought that it could potentially help with depression relief through a number of cannabinoids and terpenes contained within the plant that synergise through the Entourage Effect. 

The Best Marijuana Strains for Depression 

There are many strains that may help in curbing depression symptoms due to the chemical balance of cannabinoids and cannabis terpenes displayed in the cannabis plant. 

With research and user testimony indicating that medical marijuana has the potential to treat depression, many people have started using different marijuana strains as an alternative treatment for the condition. For beginners, it can be a bit daunting trying to understand the differences between indica strains, sativa strains and CBD strains. 

Indeed, understanding the type of cannabis strains best suited to your needs is vital when using medical marijuana so, to help you on your way, we have compiled a list of some of the best strains for treating depression.

Pineapple Express

An increasingly popular choice and one of the best strains for treating depression is the world-famous hybrid Pineapple Express. This wonderfully uplifting strain boasts the combination of effectiveness and flavour or its parents, Trainwreck and Hawaiian.

The heavy-hitting combination of Trainwreck and Hawaiian produces a wonderful Sativa dominant hybrid with a THC ratio somewhere between 17-20% with low CBD readings of less than 1%.

With a terpene profile that contains caryophyllene, limonene and myrcene, this hugely popular cannabis cup winner can help to energize the body, and improve productivity, making it an excellent strain to treat depression.

Blue Dream

A Sativa dominant hybrid, with high levels of THC, Blue Dream is thought to be one of the best strains for relaxing both mind and body which also makes it one of the best cannabis strains for depression. 

With a high THC ratio (approaching 20%) Blue Dream is one of the more potent strains and thought to be particularly effective in the treatment of stress and depression. Blue Dream ́s terpene profile shows high levels of limonene, pinene, and myrcene that may help to control mood disorders.

A cross of Blueberry with Haze, Blue Dream is a sativa strain that achieves full-body relaxation with some subtle cerebral stimulation. With a sweet berry aroma similar to that of its Blueberry parent, Blue Dream can help to treat depression without any heavy sedative effects. As such, Blue Dream is a popular daytime medicine for those looking for a little depression relief. 

Sour Diesel

Commonly known as Sour D, this fantastic hybrid strain has the potential to aid several stress disorders, including physical pain, and, depression and anxiety.

Another sativa strain, this time a  Sativa dominant hybrid that is said to have descended from Chemdog 91 and Super Skunk, Sour Diesel is rich in terpenes caryophyllene, myrcene, and limonene that lend itself to this strains peppery, citrus-like aroma and taste. This fast-acting behemoth can produce energising cerebral effects that have made Sour Diesel a legendary strain amongst cannabis enthusiasts and medical patients looking to treat mood disorders.

With a high THC ratio between 16 and 20%,  Sour Diesel has the potential to lift your mood and energy levels, making it a great cannabis strain that could provide a strong antidepressant effect for those suffering from depression. 

Jack Herer

A descendant of Shiva Skunk and Northern Lights #5. Jack Herer is a wildly popular hybrid strain that is famed for its uplifting qualities and antidepressant effect that is said to induce both happiness and creativity.

This type of strain, a Sativa dominant hybrid, is favoured by many for their stress-relieving effects as well as their balanced blend of sativa and indica effects.

Jack Herer’s THC ratio usually sits around 15 to 20%, with its dominant terpenes terpinolene, limonene and pinene thought to be particularly useful in boosting mood and focus. With a rich, piney, woody aroma, Jack Herer is a smooth yet potent strain and amongst seasoned marijuana users, remains one of the best strains for treating depression and reducing anxiety. 

Other strains worthy of a mention include OG Kush Seeds, Super Silver Haze Seeds and any of the classic Cookies strains which can all prove to be potentially effective in reducing the symptoms of depression and anxiety.

Indeed, the potential benefits of cannabis on the mind and body seem to be endless so If you ́re one of the millions suffering from depression and you’re interested in growing your own cannabis to help treat depression, please visit our growing community for more information on our huge selection of award-winning and popular strains for depression relief.

We have a vast range of seeds including sativa and indica strains, CBD strains, CBD oils and much more to choose from including popular strains like Mango Kush, Girl Scout Cookies and Northern lights.

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    Blueberry

    Autoflowering | Medicinal

    Don’t let the name confuse you, Blueberry really is cannabis. These beautiful Blueberry seeds come from our own Guru Seeds collection. If you want to buy blueberry cannabis seeds, try growing them outdoors for a quick, easy and high yielding harvest in climates that are cold and sunny.

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    Northern Lights

    Autoflowering, Feminized, Regular | Medicinal

    In the ever-evolving world of cannabis seeds and strains, Northern Lights is a tried and true classic. Thanks to its Thai and Afghani landrace strain parents, the Northern Lights strain is an indica dominant famed cannabis cup winner, popular for its relaxing, stress-relieving and uplifting effects. 

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    Chocolute F2

    Regular | Medicinal

    Absolute Seeds got creative with Chocolope, breeding in a second round of one parent to create a strain of rare dankness: Chocolute F2. Originating from Mexican and Thai landrace strains, Chocolute F2’s exotic seeds are moderately easy to grow, have a short flowering stage and produce an average-to-high yield of dense sativa-dominant buds.

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    Critigal +

    Feminized | Medicinal

    Absolute Seeds took the popular Critical Mass one step further to create Critigal+, an easy to grow, short flowering and high yielding seed. A balanced indica-sativa hybrid bred from fast-growing Afghan and Skunk cannabis seeds, the earthy and herbal aromas give the critical strain a sweet and fruity flavour.

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    San Fernando Valley OG

    | Medicinal

    San Fernando Valley OG (or SFV OG) marijuana is a popular sativa-dominant hybrid strain from Concrete Jungle Seeds. The calming, euphoric buzz offered by this potent strain has made it a new favourite among cannabis enthusiasts, following in the footsteps of its legendary parent, OG Kush. 

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    Concrete Zkittlez

    Feminized | Medicinal

    Created by Concrete Jungle Seeds, Concrete Zkittlez is an exceptional indica dominant hybrid with a sweet and fruity scent that will leave you calm and relaxed. Hailing from a robust genetic background of parent strains Gorilla Glue and Zkittlez, this powerful cannabis strain delivers a heavy harvest after a flowering time of just eight weeks.

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    Lemon Trip

    | Medicinal

    Take a trip down the lemon lane, with these highly exotic seeds brought to us by the experts at Positronic Seeds. Lemon Trip is a sativa-dominant delight with a highly uplifting effect and refreshing citrus flavour.

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    Rittus Haze

    Feminized | Medicinal

    Most seasoned cannabis consumers will attest to the fact that few varieties can match the high-energy, creative buzz afforded by haze strains. Brought to you by Absolute Seeds, Rittus Haze is a new addition to the potent haze strains.

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    Jack Herer

    Feminized | Medicinal

    Jack Herer is a celebrated hybrid strain that is undoubtedly one of the most famous cannabis strains available today. Named after the marijuana activist and author of the Emperor Wears No Clothes, this particular breed of Jack Herer cannabis seeds comes from our very own Guru Seeds range.

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    Grapefruit Diesel

    Feminized | Medicinal

    Brought to you by the seedbank, Concrete Jungle Seeds, Grapefruit Diesel is an indica dominant hybrid strain with a mild THC level of around 12%, providing a smooth, cerebral buzz conducive to productivity and creativity. This delightful hybrid marijuana strain is a beautiful love letter to its lineage, with a distinct aroma and fruity flavour to set it apart.

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    Blue Rose

    Feminized | Medicinal

    Brought to you by the experts at the Rockwell Seeds, Blue Rose is an easy to grow, indica dominant hybrid strain with a high THC level and a fast flowering time. Blue Rose is a perfect hybrid that combines a fast-acting high with a memorable flavour that makes it truly top-shelf material. 

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    Nata Naranja

    Autoflowering, Feminized | Medicinal

    Nata Naranja Auto is a fast flowering, indica-dominant cannabis strain from Concrete Jungle Seeds. With aromas and flavours as fruity as its name, this potent hybrid is making quite a name for itself in seed banks across the world.

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    Lambs Breath x AK-49

    Feminized | Medicinal

    A potent powerhouse not for the faint-hearted, Lambs Breath x AK 49, by renowned seeds company Vision Seeds, is a fiercely commanding cannabis strain, guaranteed to blast away any ill-feeling, taking you from under the weather, to high above the clouds and beyond. 

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    Doctor Jamaica

    Autoflowering, Regular | Medicinal

    A cut off the old block, the Doctor Jamaica cannabis strain is a phenotype of the old-school classic and strain hunters favourite from the U.S, California Orange, also affectionately known as Cali-O. Brought to you by Dutch seed bank Vision Seeds, Doctor Jamaica cannabis seeds are easy to grow, with a taste somewhat reminiscent of delicious freshly-squeezed oranges.

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    Amnesia Haze

    Autoflowering, Feminized | Medicinal

    A combination of South Asian indica and Jamaican landrace strains, Amnesia Haze cannabis seeds, from our own Guru Seeds range, is easily one of the most popular sativa dominant haze strains available today. Winner of multi cannabis cups and one of the most requested sativa dominant strain types in Dutch coffee shops and seed banks, this high THC level marijuana seed is nothing short of a cannabis legend.

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Don’t worry, we handle your order discretely

To ensure this, we use plain 20x27 white bubble wrap envelopes without any visible labelling except for your adres and our return address.
Our company name will read as “Guru Trading S.L”. No other company labels, receipts or any references to cannabis are included on the envelope.

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At Guru we make sure your order is handled discreetly and with the utmost care and privacy.
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What our users say

All good ,seeds arrived on time packed well, hopefully let you know how it works out in a few months
John. Smit
John. Smit
17:34 04 Oct 22
The best seeds i ever bought, Popped 2 seed in 2 days, they are 1 week old and they already 2 inches tall
Robert Lynch
Robert Lynch
17:23 24 Aug 22
Quick, easy, a high quality product, and followup to ensure your success with their product.I would easily recommend this company to others.
Laurie Pop
Laurie Pop
17:50 16 Aug 22
It is great to buy seeds now that it is legal it makes you grow with plants that grow with love and lightPeace to heavens good willMay I Rest In PeacePut the blunt down and pick it up because blunts don’t have legsAnd weed can’t speak unless you make itCuz this is purgatory riightThe bud that doesn’t breathe muchKilling trees that can move is bad luck
Mitchell Habiger
Mitchell Habiger
02:36 08 Mar 22
Took a little longer than was hoping but was also around the holidays so that's to be expected. I did receive my package and support was great about responding back to me everytime I would email them. Overall am happy to do business with again in the future thanks again!!!!
Bruce Cummings
Bruce Cummings
12:44 11 Feb 22
I placed 1 order on the 21st and another order on the 30th of November because of the incredible sale they were running and both of my orders arrived before Christmas. I was very impressed that they both delivered in timely manner. With the vast selection and a good price, I will be doing business with them again. Great job MGS.
Darrell Taylor
Darrell Taylor
19:09 26 Dec 21
Giving you five stars just for the genetics you have and for uk shipping.. but I placed my older last wednesday but still not had a email to confirm shipping, i paid for express delivery is there anytime I should be expecting a dispatch email?Thanks
D H
D H
10:30 22 Nov 21

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