Cannabis can help with depression through a number of cannabinoids and terpenes that work together through the Entourage Effect. One of the main ways cannabis combats depression is due to the positive effect CBD has on the production of serotonin by acting on the 5HT1A receptors in the brain. This effect is amplified by terpenes such as limonene and caryophyllene. 

THC, on its own, acts on the CB1/CB2 receptors, creating a buffer against depression due to its psychoactive effect (in low to medium doses). Together, THC and CBD can alleviate the major symptoms of depression like; insomnia, fatigue, loss of appetite and chronic pain.

According to the World Health Organisation (WHO more than 300 million people across the world experience depression. If you’re experiencing anxiety, low self-esteem, chronic stress and or a lack of appetite and sleep, there is a distinct possibility that you could be one of those millions who is currently fighting depression.

But have you considered the possibility that medical marijuana could actually be used to treat depression?

The common symptoms of depression include continuous low mood or sadness, feeling hopeless and helpless, having low self-esteem and or feelings of anxiety.

While pharmaceutical drugs remain the most common treatments for depression, many more people are now considering several alternatives like medical cannabis. 

Indeed, in recent years, a growing body of scientific research has come to light, indicating strongly that medical marijuana has serious potential in helping to reduce the symptoms related to depression.

Research Highlights the Efficacy of Cannabis as a Treatment for Depression

The fascinating world of cannabis health continues to arouse the curiosity of scientists around the globe. As such, it was only natural for them to study the potential effects and medical benefits that medical cannabis could have when used as a treatment for the depression crisis that seems to be engulfing so much of our planet.

In September of 2019, a study published in the Journal of Affective Disorders, suggested that inhaling cannabis can significantly reduce short-term levels of depression. Of those taking part in the analysis, 89.3% experienced a significant reduction in feelings of depression. 

The analysis also revealed that cannabis was effective in reducing anxiety (over the short-term) and stress. Another study conducted in 2014 was carried out to understand the effects of CBD, one of the dominant cannabinoids in the cannabis plant. The analysis revealed that CBD interacted with the serotonin receptors in our brain, which, in turn, helped to lower anxiety and depression levels. 

As the level of research on cannabis increases, It is now thought that it could potentially help with depression relief through a number of cannabinoids and terpenes contained within the plant that synergise through the Entourage Effect. 

The Best Marijuana Strains for Depression 

There are many strains that may help in curbing depression symptoms due to the chemical balance of cannabinoids and cannabis terpenes displayed in the cannabis plant. 

With research and user testimony indicating that medical marijuana has the potential to treat depression, many people have started using different marijuana strains as an alternative treatment for the condition. For beginners, it can be a bit daunting trying to understand the differences between indica strains, sativa strains and CBD strains. 

Indeed, understanding the type of cannabis strains best suited to your needs is vital when using medical marijuana so, to help you on your way, we have compiled a list of some of the best strains for treating depression.

Pineapple Express

An increasingly popular choice and one of the best strains for treating depression is the world-famous hybrid Pineapple Express. This wonderfully uplifting strain boasts the combination of effectiveness and flavour or its parents, Trainwreck and Hawaiian.

The heavy-hitting combination of Trainwreck and Hawaiian produces a wonderful Sativa dominant hybrid with a THC ratio somewhere between 17-20% with low CBD readings of less than 1%.

With a terpene profile that contains caryophyllene, limonene and myrcene, this hugely popular cannabis cup winner can help to energize the body, and improve productivity, making it an excellent strain to treat depression.

Blue Dream

A Sativa dominant hybrid, with high levels of THC, Blue Dream is thought to be one of the best strains for relaxing both mind and body which also makes it one of the best cannabis strains for depression. 

With a high THC ratio (approaching 20%) Blue Dream is one of the more potent strains and thought to be particularly effective in the treatment of stress and depression. Blue Dream ́s terpene profile shows high levels of limonene, pinene, and myrcene that may help to control mood disorders.

A cross of Blueberry with Haze, Blue Dream is a sativa strain that achieves full-body relaxation with some subtle cerebral stimulation. With a sweet berry aroma similar to that of its Blueberry parent, Blue Dream can help to treat depression without any heavy sedative effects. As such, Blue Dream is a popular daytime medicine for those looking for a little depression relief. 

Sour Diesel

Commonly known as Sour D, this fantastic hybrid strain has the potential to aid several stress disorders, including physical pain, and, depression and anxiety.

Another sativa strain, this time a  Sativa dominant hybrid that is said to have descended from Chemdog 91 and Super Skunk, Sour Diesel is rich in terpenes caryophyllene, myrcene, and limonene that lend itself to this strains peppery, citrus-like aroma and taste. This fast-acting behemoth can produce energising cerebral effects that have made Sour Diesel a legendary strain amongst cannabis enthusiasts and medical patients looking to treat mood disorders.

With a high THC ratio between 16 and 20%,  Sour Diesel has the potential to lift your mood and energy levels, making it a great cannabis strain that could provide a strong antidepressant effect for those suffering from depression. 

Jack Herer

A descendant of Shiva Skunk and Northern Lights #5. Jack Herer is a wildly popular hybrid strain that is famed for its uplifting qualities and antidepressant effect that is said to induce both happiness and creativity.

This type of strain, a Sativa dominant hybrid, is favoured by many for their stress-relieving effects as well as their balanced blend of sativa and indica effects.

Jack Herer’s THC ratio usually sits around 15 to 20%, with its dominant terpenes terpinolene, limonene and pinene thought to be particularly useful in boosting mood and focus. With a rich, piney, woody aroma, Jack Herer is a smooth yet potent strain and amongst seasoned marijuana users, remains one of the best strains for treating depression and reducing anxiety. 

Other strains worthy of a mention include OG Kush Seeds, Super Silver Haze Seeds and any of the classic Cookies strains which can all prove to be potentially effective in reducing the symptoms of depression and anxiety.

Indeed, the potential benefits of cannabis on the mind and body seem to be endless so If you ́re one of the millions suffering from depression and you’re interested in growing your own cannabis to help treat depression, please visit our growing community for more information on our huge selection of award-winning and popular strains for depression relief.

We have a vast range of seeds including sativa and indica strains, CBD strains, CBD oils and much more to choose from including popular strains like Mango Kush, Girl Scout Cookies and Northern lights.

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    Forbidden Fruit Cake

    Feminized | Medicinal

    Full of delightful flavours and opulent purple hues, Forbidden Fruit Cake from the Puig Seedbank is a tasty hybrid strain that matures into a truly sturdy plant capable of delivering an exceptional yield.

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    Fruit Drops

    Feminized | Medicinal

    A wonderfully fruity experience, Fruit Drops from the Puig Seedbank is an evenly balanced hybrid strain that offers an excellent and rapid yield while also delivering an emphatic flavour profile.

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    Laughing Buddha

    Feminized | Medicinal

    For a more amusing way to attain enlightenment, try Laughing Buddha – a High Times Cannabis cup-winning Sativa strain from Barney’s Farm with a mirthful and meditative psychoactive style that’s the perfect sacred medicine for giggling your way to a higher state of consciousness.

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    Blueberry Muffin

    Feminized, Regular | Medicinal

    Fresh baked breakfast flavours and energizing indica effects are what growers can expect from Blueberry Muffin – an Emerald Cup-winning hybrid that’s a firm favourite of the Humboldt Seed co.

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    Malasana Gelato

    Feminized | Medicinal

    Adding a little Spanish flavour to the traditional Cookies recipe, Malasana Gelato is a sugary and unashamedly stylish high-THC treat from Exotic Seeds that stands in fitting tributing to the hipster home district it’s named after.

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    Lemon Drip

    Feminized | Medicinal

    With its award-winning ancestry, tongue-tingling lemony flavour, and stimulating sativa-leaning effects, Lemon Drip from the Exotic Genetix seedbank may be the marijuana world’s next citrus superstar!

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    Pannacotta

    Regular | Medicinal

    Almost good enough to serve for dessert, Pannacotta is an indica-leaning, milk and cookies flavoured mashup from the Oni Seeds company meant only for those of the most refined palettes and the strongest psychoactive tolerance.

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    Melon Fizz

    Feminized | Medicinal

    The headline strain from the Archive Seed Bank’s new Moonbow Collection, Melon Fizz, is a sweet-as-they-come indica-dominant hybrid. This Zkittlez-rich cannabis strain has a flavour profile that’ll make your mouth water and a THC level that’ll make your head spin!

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    Jelly Rancher

    Feminized | Medicinal

    Purpose bred for big kids with the biggest THC tolerances, Jelly Rancher is a sweet and juicy sativa strain from Humboldt Seeds that boasts one of the highest cannabinoid contents commercially available — ideal for connoisseurs who like their candy with a strong cerebral kick!

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    Cake Face

    Regular | Medicinal

    Cake Face is a high THC beauty from the Archive Seedbank that is rich in OG heritage. This indica dominant hybrid cannabis strain is high yielding, fast flowering, and offers up a taste extravaganza of sweet, floral goodness!

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    Mimosa x Orange Punch

    Feminized | Medicinal

    A cultivator’s fantasy from Barney’s Farm’s skilled breeders, Mimosa x Orange Punch cannabis seeds are a high THC level, indica-dominant dream with a citrusy, candy flavour, an uplifting high, and a large indoor and outdoor harvest.

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    Guava Jelly

    Feminized | Medicinal

    An incredibly complex cannabis creation that’s guaranteed to get you in the mood for lovin’, Guava Jelly is a fruity 50/50 hybrid from Sensi Seeds with AAA genetics gleaned from four of the finest indica and sativa strains the marijuana world has to offer.

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    Luv Muffin

    Feminized | Medicinal

    Perfect when you’re in need of a little psychoactive TLC, Luv Muffin – a cherished Cookies and Kush mashup from the Rare Dankness seedbank – is like a warm and fuzzy hug in marijuana form; its luscious flavour and soothing effects filling you with good vibes from dawn to dusk.

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    Killer Bees

    Feminized | Medicinal

    Sweet as honey but armed with a spicy cerebral sting, Killer Bees is a sativa-dominant three-way cannabis hybrid from the Archive Seeds company that’ll keep you buzzed for hours.

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    Purple Dragon

    Autoflowering, Feminized, Regular | Medicinal

    Slaying the competition with its fantastic colour scheme, fiery flavours, and a formidable psychoactive assault, Purple Dragon is a monstrous purple balanced hybrid from Guru Fire that’s here to chase all your worries away.

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To ensure this, we use plain 20x27 white bubble wrap envelopes without any visible labelling except for your adres and our return address.
Our company name will read as “Guru Trading S.L”. No other company labels, receipts or any references to cannabis are included on the envelope.

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What our users say

All good ,seeds arrived on time packed well, hopefully let you know how it works out in a few months
John. Smit
John. Smit
17:34 04 Oct 22
The best seeds i ever bought, Popped 2 seed in 2 days, they are 1 week old and they already 2 inches tall
Robert Lynch
Robert Lynch
17:23 24 Aug 22
Quick, easy, a high quality product, and followup to ensure your success with their product.I would easily recommend this company to others.
Laurie Pop
Laurie Pop
17:50 16 Aug 22
It is great to buy seeds now that it is legal it makes you grow with plants that grow with love and lightPeace to heavens good willMay I Rest In PeacePut the blunt down and pick it up because blunts don’t have legsAnd weed can’t speak unless you make itCuz this is purgatory riightThe bud that doesn’t breathe muchKilling trees that can move is bad luck
Mitchell Habiger
Mitchell Habiger
02:36 08 Mar 22
Took a little longer than was hoping but was also around the holidays so that's to be expected. I did receive my package and support was great about responding back to me everytime I would email them. Overall am happy to do business with again in the future thanks again!!!!
Bruce Cummings
Bruce Cummings
12:44 11 Feb 22
I placed 1 order on the 21st and another order on the 30th of November because of the incredible sale they were running and both of my orders arrived before Christmas. I was very impressed that they both delivered in timely manner. With the vast selection and a good price, I will be doing business with them again. Great job MGS.
Darrell Taylor
Darrell Taylor
19:09 26 Dec 21
Giving you five stars just for the genetics you have and for uk shipping.. but I placed my older last wednesday but still not had a email to confirm shipping, i paid for express delivery is there anytime I should be expecting a dispatch email?Thanks
D H
D H
10:30 22 Nov 21

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