Cannabis can help with depression through a number of cannabinoids and terpenes that work together through the Entourage Effect. One of the main ways cannabis combats depression is due to the positive effect CBD has on the production of serotonin by acting on the 5HT1A receptors in the brain. This effect is amplified by terpenes such as limonene and caryophyllene. 

THC, on its own, acts on the CB1/CB2 receptors, creating a buffer against depression due to its psychoactive effect (in low to medium doses). Together, THC and CBD can alleviate the major symptoms of depression like; insomnia, fatigue, loss of appetite and chronic pain.

According to the World Health Organisation (WHO more than 300 million people across the world experience depression. If you’re experiencing anxiety, low self-esteem, chronic stress and or a lack of appetite and sleep, there is a distinct possibility that you could be one of those millions who is currently fighting depression.

But have you considered the possibility that medical marijuana could actually be used to treat depression?

The common symptoms of depression include continuous low mood or sadness, feeling hopeless and helpless, having low self-esteem and or feelings of anxiety.

While pharmaceutical drugs remain the most common treatments for depression, many more people are now considering several alternatives like medical cannabis. 

Indeed, in recent years, a growing body of scientific research has come to light, indicating strongly that medical marijuana has serious potential in helping to reduce the symptoms related to depression.

Research Highlights the Efficacy of Cannabis as a Treatment for Depression

The fascinating world of cannabis health continues to arouse the curiosity of scientists around the globe. As such, it was only natural for them to study the potential effects and medical benefits that medical cannabis could have when used as a treatment for the depression crisis that seems to be engulfing so much of our planet.

In September of 2019, a study published in the Journal of Affective Disorders, suggested that inhaling cannabis can significantly reduce short-term levels of depression. Of those taking part in the analysis, 89.3% experienced a significant reduction in feelings of depression. 

The analysis also revealed that cannabis was effective in reducing anxiety (over the short-term) and stress. Another study conducted in 2014 was carried out to understand the effects of CBD, one of the dominant cannabinoids in the cannabis plant. The analysis revealed that CBD interacted with the serotonin receptors in our brain, which, in turn, helped to lower anxiety and depression levels. 

As the level of research on cannabis increases, It is now thought that it could potentially help with depression relief through a number of cannabinoids and terpenes contained within the plant that synergise through the Entourage Effect. 

The Best Marijuana Strains for Depression 

There are many strains that may help in curbing depression symptoms due to the chemical balance of cannabinoids and cannabis terpenes displayed in the cannabis plant. 

With research and user testimony indicating that medical marijuana has the potential to treat depression, many people have started using different marijuana strains as an alternative treatment for the condition. For beginners, it can be a bit daunting trying to understand the differences between indica strains, sativa strains and CBD strains. 

Indeed, understanding the type of cannabis strains best suited to your needs is vital when using medical marijuana so, to help you on your way, we have compiled a list of some of the best strains for treating depression.

Pineapple Express

An increasingly popular choice and one of the best strains for treating depression is the world-famous hybrid Pineapple Express. This wonderfully uplifting strain boasts the combination of effectiveness and flavour or its parents, Trainwreck and Hawaiian.

The heavy-hitting combination of Trainwreck and Hawaiian produces a wonderful Sativa dominant hybrid with a THC ratio somewhere between 17-20% with low CBD readings of less than 1%.

With a terpene profile that contains caryophyllene, limonene and myrcene, this hugely popular cannabis cup winner can help to energize the body, and improve productivity, making it an excellent strain to treat depression.

Blue Dream

A Sativa dominant hybrid, with high levels of THC, Blue Dream is thought to be one of the best strains for relaxing both mind and body which also makes it one of the best cannabis strains for depression. 

With a high THC ratio (approaching 20%) Blue Dream is one of the more potent strains and thought to be particularly effective in the treatment of stress and depression. Blue Dream ́s terpene profile shows high levels of limonene, pinene, and myrcene that may help to control mood disorders.

A cross of Blueberry with Haze, Blue Dream is a sativa strain that achieves full-body relaxation with some subtle cerebral stimulation. With a sweet berry aroma similar to that of its Blueberry parent, Blue Dream can help to treat depression without any heavy sedative effects. As such, Blue Dream is a popular daytime medicine for those looking for a little depression relief. 

Sour Diesel

Commonly known as Sour D, this fantastic hybrid strain has the potential to aid several stress disorders, including physical pain, and, depression and anxiety.

Another sativa strain, this time a  Sativa dominant hybrid that is said to have descended from Chemdog 91 and Super Skunk, Sour Diesel is rich in terpenes caryophyllene, myrcene, and limonene that lend itself to this strains peppery, citrus-like aroma and taste. This fast-acting behemoth can produce energising cerebral effects that have made Sour Diesel a legendary strain amongst cannabis enthusiasts and medical patients looking to treat mood disorders.

With a high THC ratio between 16 and 20%,  Sour Diesel has the potential to lift your mood and energy levels, making it a great cannabis strain that could provide a strong antidepressant effect for those suffering from depression. 

Jack Herer

A descendant of Shiva Skunk and Northern Lights #5. Jack Herer is a wildly popular hybrid strain that is famed for its uplifting qualities and antidepressant effect that is said to induce both happiness and creativity.

This type of strain, a Sativa dominant hybrid, is favoured by many for their stress-relieving effects as well as their balanced blend of sativa and indica effects.

Jack Herer’s THC ratio usually sits around 15 to 20%, with its dominant terpenes terpinolene, limonene and pinene thought to be particularly useful in boosting mood and focus. With a rich, piney, woody aroma, Jack Herer is a smooth yet potent strain and amongst seasoned marijuana users, remains one of the best strains for treating depression and reducing anxiety. 

Other strains worthy of a mention include OG Kush Seeds, Super Silver Haze Seeds and any of the classic Cookies strains which can all prove to be potentially effective in reducing the symptoms of depression and anxiety.

Indeed, the potential benefits of cannabis on the mind and body seem to be endless so If you ́re one of the millions suffering from depression and you’re interested in growing your own cannabis to help treat depression, please visit our growing community for more information on our huge selection of award-winning and popular strains for depression relief.

We have a vast range of seeds including sativa and indica strains, CBD strains, CBD oils and much more to choose from including popular strains like Mango Kush, Girl Scout Cookies and Northern lights.

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    Fastberry

    Autoflowering | Medicinal

    With great performance potential, Fastberry is an indica-dominant strain developed from old school Blueberry lineage that’s easily recognized and loved by those who enjoy sweeter cannabis varieties.

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    Lithium OG Kush

    Feminized | Medicinal

    Lithium OG Kush is a delightful indica-dominant hybrid, with a THC content pushing 20%.  The result of a crossing between OG Kush and Master Kush, Lithium OG Kush is famed for its wonderful chilled-out and antidepressant qualities. 

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    Swiss Cheese

    | Medicinal

    Nirvana Seeds revived their well-known Swiss Miss strain by crossing her genetics with Skunk#1 to create this cheesy, pungent indica. Swiss Cheese has medium THC levels and high CBD levels. Her taste is funky and flavorful, and her aroma will undoubtedly attract some attention. Swiss Cheese is perfect for an evening dinner party with good friends as she promotes lively debate.

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    Sterling Haze

    | Medicinal

    She may be called ‘Sterling’ Haze, but with some experience and attention, you could have a gold mine on your hands. Nirvana Seeds created this strain by combining superior sativa genetics with an eye for potency and flavor. Rumor has it that this strain even packs a high strong enough to reset your tolerance.

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    CBD Skunk Haze

    Feminized | Medicinal

    Containing equal levels of CBD and THC, CBD Skunk Haze is a clear dedication to the medical marijuana community and one of the most sought-after cannabis hybrids that’s far more than its incredible parent strains.

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    Euforia

    Feminized | Medicinal

    Nearly pure sativa, this hybrid strain is and an ideal choice for wake and bake. If that’s your style, of course, known for its ability to make you feel more than euphoric.

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    Jorge’s Diamonds #1

    Feminized | Medicinal

    Specially selected genetics from the famous Dutch Passion Research Gene Bank were selected by renowned cannabis guru, Jorges Cervantes, to create Jorge’s Diamonds #1. This sweet and potent strain produces bud as sparkly as the name suggests: a real jewel in this breeder´s crown.

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    Mazar

    | Medicinal

    This multiple prize winning indica remains one of Dutch Passion´s best sellers. A potent combination of Skunk #1 x Afghani, Mazar is an indica-dominant strain that will leave you blissed out for hours, 19.5% THC.

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    Orange Hill Special

    | Medicinal

    A unique and delicious flower from Dutch Passion’s skunk collection, Orange Hill Special is the tangy combination of Orange Bud and Californian Orange. The result is an evenly balanced indica/sativa hybrid strain with a high THC content, pushing over 20%. 

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    Snowbud

    Feminized | Medicinal

    A ‘high altitude’ strain from Dutch Passion, Snowbud is a 60/40 sativa/indica hybrid, that combines very strong Afghani x South African genetics. The high is light and happy, and she grows well in cooler Northern European climates thanks to her breeding in the Swiss Alps.  8-12% THC.

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    Fast Eddy CBD

    Autoflowering | Medicinal

    Thanks to Royal Queen Seeds, the benefits of CBD strains like Fast Eddy are accessible to all. Light in its effect, broad in its medicinal applications and quick and easy-to-grow – everybody wins.

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    The Ultimate

    Feminized | Medicinal

    The Ultimate from Dutch Passion is a 50/50 hybrid, but it is the sativa effects that come through most strongly. She is known for her wonderful, sativa high, but also for her reliability and high yields as an indoor grow plant. One recommended for connaisseurs.

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    CBD Charlotte’s Angel

    Autoflowering, Feminized | Medicinal

    A remarkable medicinal strain, Charlotte’s Angel from Dutch Passion is an 80/20  sativa-dominant hybrid that is non-psychoactive. She provides all the flavor of strong THC varieties but without the high. Yet, you will still feel the distinctive mellowing effects of the crazily high concentration of CBD (15%).

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    Sweet Skunk

    Autoflowering | Medicinal

    A super fast automatic strain that is highly reliable for growing outdoors. An excellent choice for beginner growers, as she grows dense popcorn sized buds with a high calyx to leaf ratio of sticky sweet funk. Great for a consistent yield in all European climates.

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    Kushage

    | Medicinal

    American West Coast genetics of OG Kush combined with S.A.G.E. to create an excellent sativa-leaning hybrid with energizing and uplifting effects. 

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To ensure this, we use plain 20x27 white bubble wrap envelopes without any visible labelling except for your adres and our return address.
Our company name will read as “Guru Trading S.L”. No other company labels, receipts or any references to cannabis are included on the envelope.

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What our users say

All good ,seeds arrived on time packed well, hopefully let you know how it works out in a few months
John. Smit
John. Smit
17:34 04 Oct 22
The best seeds i ever bought, Popped 2 seed in 2 days, they are 1 week old and they already 2 inches tall
Robert Lynch
Robert Lynch
17:23 24 Aug 22
Quick, easy, a high quality product, and followup to ensure your success with their product.I would easily recommend this company to others.
Laurie Pop
Laurie Pop
17:50 16 Aug 22
It is great to buy seeds now that it is legal it makes you grow with plants that grow with love and lightPeace to heavens good willMay I Rest In PeacePut the blunt down and pick it up because blunts don’t have legsAnd weed can’t speak unless you make itCuz this is purgatory riightThe bud that doesn’t breathe muchKilling trees that can move is bad luck
Mitchell Habiger
Mitchell Habiger
02:36 08 Mar 22
Took a little longer than was hoping but was also around the holidays so that's to be expected. I did receive my package and support was great about responding back to me everytime I would email them. Overall am happy to do business with again in the future thanks again!!!!
Bruce Cummings
Bruce Cummings
12:44 11 Feb 22
I placed 1 order on the 21st and another order on the 30th of November because of the incredible sale they were running and both of my orders arrived before Christmas. I was very impressed that they both delivered in timely manner. With the vast selection and a good price, I will be doing business with them again. Great job MGS.
Darrell Taylor
Darrell Taylor
19:09 26 Dec 21
Giving you five stars just for the genetics you have and for uk shipping.. but I placed my older last wednesday but still not had a email to confirm shipping, i paid for express delivery is there anytime I should be expecting a dispatch email?Thanks
D H
D H
10:30 22 Nov 21

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